| Title |
HIV DNA Reservoir Increases Risk for Cognitive Disorders in cART-Naïve Patients
|
|---|---|
| Published in |
PLOS ONE, July 2013
|
| DOI | 10.1371/journal.pone.0070164 |
| Pubmed ID | |
| Authors |
Victor G. Valcour, Jintanat Ananworanich, Melissa Agsalda, Napapon Sailasuta, Thep Chalermchai, Alexandra Schuetz, Cecilia Shikuma, Chin-Yuan Liang, Supunee Jirajariyavej, Pasiri Sithinamsuwan, Somporn Tipsuk, David B. Clifford, Robert Paul, James L. K. Fletcher, Mary A. Marovich, Bonnie M. Slike, Victor DeGruttola, Bruce Shiramizu |
| Abstract |
Cognitive impairment remains frequent in HIV, despite combination antiretroviral therapy (cART). Leading theories implicate peripheral monocyte HIV DNA reservoirs as a mechanism for spread of the virus to the brain. These reservoirs remain present despite cART. The objective of this study was to determine if the level of HIV DNA in CD14(+) enriched monocytes predicted cognitive impairment and brain injury. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 67% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 78 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 3% |
| Unknown | 76 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 11 | 14% |
| Student > Doctoral Student | 11 | 14% |
| Researcher | 10 | 13% |
| Professor | 7 | 9% |
| Student > Bachelor | 6 | 8% |
| Other | 18 | 23% |
| Unknown | 15 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 24 | 31% |
| Psychology | 9 | 12% |
| Neuroscience | 5 | 6% |
| Agricultural and Biological Sciences | 5 | 6% |
| Immunology and Microbiology | 4 | 5% |
| Other | 10 | 13% |
| Unknown | 21 | 27% |