| Title |
A Robotics-Based Behavioral Paradigm to Measure Anxiety-Related Responses in Zebrafish
|
|---|---|
| Published in |
PLOS ONE, July 2013
|
| DOI | 10.1371/journal.pone.0069661 |
| Pubmed ID | |
| Authors |
Valentina Cianca, Tiziana Bartolini, Maurizio Porfiri, Simone Macrì |
| Abstract |
Zebrafish are gaining momentum as a laboratory animal species for the study of anxiety-related disorders in translational research, whereby they serve a fundamental complement to laboratory rodents. Several anxiety-related behavioral paradigms, which rest upon the presentation of live predatorial stimuli, may yield inconsistent results due to fatigue, habituation, or idiosyncratic responses exhibited by the stimulus itself. To overcome these limitations, we designed and manufactured a fully controllable robot inspired by a natural aquatic predator (Indian leaf fish, Nandus nandus) of zebrafish. We report that this robot elicits aversive antipredatorial reactions in a preference test and that data obtained therein correlate with data observed in traditional anxiety- and fear-related tests (light/dark preference and shelter-seeking). Finally, ethanol administration (0.25; 0.50; 1.00%) exerts anxiolytic effects, thus supporting the view that robotic stimuli can be used in the analysis of anxiety-related behaviors in zebrafish. |
X Demographics
The data shown below were collected from the profiles of 10 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 30% |
| Chile | 1 | 10% |
| Germany | 1 | 10% |
| France | 1 | 10% |
| United Kingdom | 1 | 10% |
| Japan | 1 | 10% |
| Unknown | 2 | 20% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 60% |
| Scientists | 4 | 40% |
Mendeley readers
The data shown below were compiled from readership statistics for 89 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 2 | 2% |
| United States | 2 | 2% |
| United Kingdom | 1 | 1% |
| Unknown | 84 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 18 | 20% |
| Researcher | 12 | 13% |
| Student > Bachelor | 11 | 12% |
| Student > Master | 10 | 11% |
| Student > Doctoral Student | 4 | 4% |
| Other | 16 | 18% |
| Unknown | 18 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 26 | 29% |
| Neuroscience | 8 | 9% |
| Engineering | 7 | 8% |
| Psychology | 6 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 6% |
| Other | 15 | 17% |
| Unknown | 22 | 25% |