Title |
Cycle Checkpoint Abnormalities during Dementia: A Plausible Association with the Loss of Protection against Oxidative Stress in Alzheimer’s Disease
|
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Published in |
PLOS ONE, July 2013
|
DOI | 10.1371/journal.pone.0068361 |
Pubmed ID | |
Authors |
Pavel Katsel, Weilun Tan, Peter Fam, Dushyant P. Purohit, Vahram Haroutunian |
Abstract |
Increasing evidence suggests an association between neuronal cell cycle (CCL) events and the processes that underlie neurodegeneration in Alzheimer's disease (AD). Elevated levels of oxidative stress markers and mitochondrial dysfunction are also among early events in AD. Recent studies have reported the role of CCL checkpoint proteins and tumor suppressors, such as ATM and p53 in the control of glycolysis and oxidative metabolism in cancer, but their involvement in AD remains uncertain. |
Mendeley readers
The data shown below were compiled from readership statistics for 69 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 3% |
United Kingdom | 1 | 1% |
India | 1 | 1% |
Unknown | 65 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 15 | 22% |
Researcher | 13 | 19% |
Student > Bachelor | 10 | 14% |
Student > Postgraduate | 8 | 12% |
Student > Master | 6 | 9% |
Other | 10 | 14% |
Unknown | 7 | 10% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 18 | 26% |
Biochemistry, Genetics and Molecular Biology | 10 | 14% |
Neuroscience | 8 | 12% |
Medicine and Dentistry | 8 | 12% |
Psychology | 5 | 7% |
Other | 6 | 9% |
Unknown | 14 | 20% |