Report for: Synthetic RNA Silencing of Actinorhodin Biosynthesis in Streptomyces coelicolor A3(2)

Title	Synthetic RNA Silencing of Actinorhodin Biosynthesis in Streptomyces coelicolor A3(2)
Published in	PLOS ONE, June 2013
DOI	10.1371/journal.pone.0067509
Pubmed ID	23826310
Authors	Gabriel C. Uguru, Madhav Mondhe, Shan Goh, Andrew Hesketh, Mervyn J. Bibb, Liam Good, James E. M. Stach
Abstract	We demonstrate the first application of synthetic RNA gene silencers in Streptomyces coelicolor A3(2). Peptide nucleic acid and expressed antisense RNA silencers successfully inhibited actinorhodin production. Synthetic RNA silencing was target-specific and is a new tool for gene regulation and metabolic engineering studies in Streptomyces.

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Type	Count	As %
Scientists	2	50%
Members of the public	2	50%

Mendeley readers

The data shown below were compiled from readership statistics for 60 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Readers by professional status	Count	As %
Student > Ph. D. Student	14	23%
Researcher	9	15%
Student > Bachelor	8	13%
Student > Master	8	13%
Professor > Associate Professor	7	12%
Other	9	15%
Unknown	5	8%

Readers by discipline	Count	As %
Agricultural and Biological Sciences	24	40%
Biochemistry, Genetics and Molecular Biology	21	35%
Chemistry	4	7%
Engineering	3	5%
Immunology and Microbiology	2	3%
Other	1	2%
Unknown	5	8%

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