Title |
EffiCiency and Safety of an eLectronic cigAreTte (ECLAT) as Tobacco Cigarettes Substitute: A Prospective 12-Month Randomized Control Design Study
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Published in |
PLOS ONE, June 2013
|
DOI | 10.1371/journal.pone.0066317 |
Pubmed ID | |
Authors |
Pasquale Caponnetto, Davide Campagna, Fabio Cibella, Jaymin B. Morjaria, Massimo Caruso, Cristina Russo, Riccardo Polosa |
Abstract |
Electronic cigarettes (e-cigarettes) are becoming increasingly popular with smokers worldwide. Users report buying them to help quit smoking, to reduce cigarette consumption, to relieve tobacco withdrawal symptoms, and to continue having a 'smoking' experience, but with reduced health risks. Research on e-cigarettes is urgently needed in order to ensure that the decisions of regulators, healthcare providers and consumers are based on science. Methods ECLAT is a prospective 12-month randomized, controlled trial that evaluates smoking reduction/abstinence in 300 smokers not intending to quit experimenting two different nicotine strengths of a popular e-cigarette model ('Categoria'; Arbi Group Srl, Italy) compared to its non-nicotine choice. GroupA (n = 100) received 7.2 mg nicotine cartridges for 12 weeks; GroupB (n = 100), a 6-week 7.2 mg nicotine cartridges followed by a further 6-week 5.4 mg nicotine cartridges; GroupC (n = 100) received no-nicotine cartridges for 12 weeks. The study consisted of nine visits during which cig/day use and exhaled carbon monoxide (eCO) levels were measured. Smoking reduction and abstinence rates were calculated. Adverse events and product preferences were also reviewed. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 34 | 19% |
United Kingdom | 32 | 18% |
France | 6 | 3% |
Canada | 6 | 3% |
Australia | 6 | 3% |
Germany | 3 | 2% |
Spain | 3 | 2% |
Argentina | 2 | 1% |
Sweden | 1 | <1% |
Other | 16 | 9% |
Unknown | 69 | 39% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 153 | 86% |
Practitioners (doctors, other healthcare professionals) | 14 | 8% |
Scientists | 7 | 4% |
Science communicators (journalists, bloggers, editors) | 3 | 2% |
Unknown | 1 | <1% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 8 | 2% |
United Kingdom | 3 | <1% |
Norway | 1 | <1% |
Malaysia | 1 | <1% |
New Zealand | 1 | <1% |
Canada | 1 | <1% |
Romania | 1 | <1% |
Denmark | 1 | <1% |
Unknown | 497 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 93 | 18% |
Researcher | 64 | 12% |
Student > Master | 57 | 11% |
Student > Ph. D. Student | 41 | 8% |
Other | 40 | 8% |
Other | 115 | 22% |
Unknown | 104 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 154 | 30% |
Psychology | 44 | 9% |
Agricultural and Biological Sciences | 35 | 7% |
Social Sciences | 31 | 6% |
Nursing and Health Professions | 29 | 6% |
Other | 98 | 19% |
Unknown | 123 | 24% |