| Title |
DGCR8-Mediated Production of Canonical Micrornas Is Critical for Regulatory T Cell Function and Stability
|
|---|---|
| Published in |
PLOS ONE, May 2013
|
| DOI | 10.1371/journal.pone.0066282 |
| Pubmed ID | |
| Authors |
Lukas T. Jeker, Xuyu Zhou, Robert Blelloch, Jeffrey A. Bluestone |
| Abstract |
Regulatory T cells (Treg) are integral for immune homeostasis. Here we demonstrate that canonical microRNAs (miRNAs) are required for Treg function because mice with DGCR8-deficient Treg cells spontaneously develop a scurfy-like disease. Using genetic lineage marking we show that absence of miRNAs leads to reduced FoxP3 expression in Treg cells in vivo. In vitro culture of purified DGCR8-deficient Treg leads to a loss of FoxP3 expression. We conclude that canonical miRNAs are essential to maintain stable FoxP3 expression and Treg function. Thus, signals interfering with miRNA homeostasis might contribute to autoimmune diseases. |
Mendeley readers
The data shown below were compiled from readership statistics for 38 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 3% |
| Netherlands | 1 | 3% |
| China | 1 | 3% |
| Unknown | 35 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 10 | 26% |
| Student > Ph. D. Student | 9 | 24% |
| Professor | 3 | 8% |
| Student > Postgraduate | 3 | 8% |
| Student > Bachelor | 2 | 5% |
| Other | 4 | 11% |
| Unknown | 7 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 14 | 37% |
| Immunology and Microbiology | 6 | 16% |
| Biochemistry, Genetics and Molecular Biology | 5 | 13% |
| Medicine and Dentistry | 4 | 11% |
| Psychology | 1 | 3% |
| Other | 1 | 3% |
| Unknown | 7 | 18% |