| Title |
Chloroquine Treatment Enhances Regulatory T Cells and Reduces the Severity of Experimental Autoimmune Encephalomyelitis
|
|---|---|
| Published in |
PLOS ONE, June 2013
|
| DOI | 10.1371/journal.pone.0065913 |
| Pubmed ID | |
| Authors |
Rodolfo Thomé, Adriel S. Moraes, André Luis Bombeiro, Alessandro dos Santos Farias, Carolina Francelin, Thiago Alves da Costa, Rosária Di Gangi, Leonilda Maria Barbosa dos Santos, Alexandre Leite Rodrigues de Oliveira, Liana Verinaud |
| Abstract |
The modulation of inflammatory processes is a necessary step, mostly orchestrated by regulatory T (Treg) cells and suppressive Dendritic Cells (DCs), to prevent the development of deleterious responses and autoimmune diseases. Therapies that focused on adoptive transfer of Treg cells or their expansion in vivo achieved great success in controlling inflammation in several experimental models. Chloroquine (CQ), an anti-malarial drug, was shown to reduce inflammation, although the mechanisms are still obscure. In this context, we aimed to access whether chloroquine treatment alters the frequency of Treg cells and DCs in normal mice. In addition, the effects of the prophylactic and therapeutic treatment with CQ on Experimental Autoimmune Encephalomyelitis (EAE), an experimental model for human Multiple Sclerosis, was investigated as well. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 20% |
| Unknown | 4 | 80% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 80% |
| Practitioners (doctors, other healthcare professionals) | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 64 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 1 | 2% |
| Unknown | 63 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 16 | 25% |
| Student > Ph. D. Student | 12 | 19% |
| Student > Master | 9 | 14% |
| Student > Doctoral Student | 4 | 6% |
| Professor > Associate Professor | 4 | 6% |
| Other | 9 | 14% |
| Unknown | 10 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 13 | 20% |
| Medicine and Dentistry | 10 | 16% |
| Immunology and Microbiology | 9 | 14% |
| Biochemistry, Genetics and Molecular Biology | 6 | 9% |
| Neuroscience | 5 | 8% |
| Other | 7 | 11% |
| Unknown | 14 | 22% |