| Title |
Pericytes Derived from Adipose-Derived Stem Cells Protect against Retinal Vasculopathy
|
|---|---|
| Published in |
PLOS ONE, May 2013
|
| DOI | 10.1371/journal.pone.0065691 |
| Pubmed ID | |
| Authors |
Thomas A. Mendel, Erin B. D. Clabough, David S. Kao, Tatiana N. Demidova-Rice, Jennifer T. Durham, Brendan C. Zotter, Scott A. Seaman, Stephen M. Cronk, Elizabeth P. Rakoczy, Adam J. Katz, Ira M. Herman, Shayn M. Peirce, Paul A. Yates |
| Abstract |
Retinal vasculopathies, including diabetic retinopathy (DR), threaten the vision of over 100 million people. Retinal pericytes are critical for microvascular control, supporting retinal endothelial cells via direct contact and paracrine mechanisms. With pericyte death or loss, endothelial dysfunction ensues, resulting in hypoxic insult, pathologic angiogenesis, and ultimately blindness. Adipose-derived stem cells (ASCs) differentiate into pericytes, suggesting they may be useful as a protective and regenerative cellular therapy for retinal vascular disease. In this study, we examine the ability of ASCs to differentiate into pericytes that can stabilize retinal vessels in multiple pre-clinical models of retinal vasculopathy. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 128 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 2 | 2% |
| Italy | 1 | <1% |
| France | 1 | <1% |
| Taiwan | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 122 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 22 | 17% |
| Student > Ph. D. Student | 17 | 13% |
| Researcher | 13 | 10% |
| Student > Bachelor | 12 | 9% |
| Student > Doctoral Student | 11 | 9% |
| Other | 16 | 13% |
| Unknown | 37 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 24 | 19% |
| Agricultural and Biological Sciences | 23 | 18% |
| Biochemistry, Genetics and Molecular Biology | 19 | 15% |
| Engineering | 9 | 7% |
| Neuroscience | 4 | 3% |
| Other | 10 | 8% |
| Unknown | 39 | 30% |