| Title |
The Ketogenic Diet and Hyperbaric Oxygen Therapy Prolong Survival in Mice with Systemic Metastatic Cancer
|
|---|---|
| Published in |
PLOS ONE, June 2013
|
| DOI | 10.1371/journal.pone.0065522 |
| Pubmed ID | |
| Authors |
Angela M. Poff, Csilla Ari, Thomas N. Seyfried, Dominic P. D’Agostino |
| Abstract |
Abnormal cancer metabolism creates a glycolytic-dependency which can be exploited by lowering glucose availability to the tumor. The ketogenic diet (KD) is a low carbohydrate, high fat diet which decreases blood glucose and elevates blood ketones and has been shown to slow cancer progression in animals and humans. Abnormal tumor vasculature creates hypoxic pockets which promote cancer progression and further increase the glycolytic-dependency of cancers. Hyperbaric oxygen therapy (HBO₂T) saturates tumors with oxygen, reversing the cancer promoting effects of tumor hypoxia. Since these non-toxic therapies exploit overlapping metabolic deficiencies of cancer, we tested their combined effects on cancer progression in a natural model of metastatic disease. |
X Demographics
The data shown below were collected from the profiles of 381 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 117 | 31% |
| United Kingdom | 15 | 4% |
| South Africa | 6 | 2% |
| Australia | 6 | 2% |
| Canada | 5 | 1% |
| Spain | 3 | <1% |
| Netherlands | 2 | <1% |
| Italy | 2 | <1% |
| Brazil | 2 | <1% |
| Other | 21 | 6% |
| Unknown | 202 | 53% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 336 | 88% |
| Practitioners (doctors, other healthcare professionals) | 30 | 8% |
| Scientists | 8 | 2% |
| Science communicators (journalists, bloggers, editors) | 6 | 2% |
| Unknown | 1 | <1% |
Mendeley readers
The data shown below were compiled from readership statistics for 333 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 6 | 2% |
| Portugal | 1 | <1% |
| Germany | 1 | <1% |
| Brazil | 1 | <1% |
| Unknown | 324 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 56 | 17% |
| Student > Bachelor | 49 | 15% |
| Researcher | 43 | 13% |
| Other | 37 | 11% |
| Student > Ph. D. Student | 32 | 10% |
| Other | 58 | 17% |
| Unknown | 58 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 91 | 27% |
| Agricultural and Biological Sciences | 45 | 14% |
| Biochemistry, Genetics and Molecular Biology | 43 | 13% |
| Nursing and Health Professions | 27 | 8% |
| Neuroscience | 8 | 2% |
| Other | 49 | 15% |
| Unknown | 70 | 21% |