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Successful Isolation of Infectious and High Titer Human Monocyte-Derived HIV-1 from Two Subjects with Discontinued Therapy

Overview of attention for article published in PLOS ONE, May 2013
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Title
Successful Isolation of Infectious and High Titer Human Monocyte-Derived HIV-1 from Two Subjects with Discontinued Therapy
Published in
PLOS ONE, May 2013
DOI 10.1371/journal.pone.0065071
Pubmed ID
Authors

Tong Wang, Younong Xu, Haiying Zhu, Thomas Andrus, Sergei B. Ivanov, Charlotte Pan, Jazel Dolores, Gregory C. Dann, Michael Zhou, Dominic Forte, Zihuan Yang, Sarah Holte, Lawrence Corey, Tuofu Zhu

Abstract

HIV-1 DNA in blood monocytes is considered a viral source of various HIV-1 infected tissue macrophages, which is also known as "Trojan horse" hypothesis. However, whether these DNA can produce virions has been an open question for years, due to the inability of isolating high titer and infectious HIV-1 directly from monocytes.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Puerto Rico 1 3%
Unknown 28 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 24%
Student > Ph. D. Student 6 21%
Student > Master 5 17%
Student > Bachelor 4 14%
Other 1 3%
Other 3 10%
Unknown 3 10%
Readers by discipline Count As %
Medicine and Dentistry 7 24%
Agricultural and Biological Sciences 6 21%
Biochemistry, Genetics and Molecular Biology 3 10%
Immunology and Microbiology 2 7%
Mathematics 1 3%
Other 5 17%
Unknown 5 17%