Title |
Routine CSF Analysis in Coccidioidomycosis Is Not Required
|
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Published in |
PLOS ONE, May 2013
|
DOI | 10.1371/journal.pone.0064249 |
Pubmed ID | |
Authors |
George Thompson, Sharon Wang, Robert Bercovitch, Michael Bolaris, Dane Van Den Akker, Sandra Taylor, Rodrigo Lopez, Antonio Catanzaro, Jose Cadena, Peter Chin-Hong, Brad Spellberg |
Abstract |
Although routinely done, there has been no evaluation of the utility of performing routine cerebrospinal fluid (CSF) examination in patients with active coccidioidomycosis and high complement fixation (IgG) antibody titers or other risk factors for disseminated infection. In our review 100% of patients diagnosed with coccidioidal meningitis had at least one sign or symptom consistent with infection of the central nervous system, headache was present in 100% of those with meningitis, while no patients without signs/symptoms of CNS infection were found to have coccidioidal meningitis, irrespective of antibody titers or other risk factors. Thus routine lumbar puncture may be unnecessary for patients with coccidioidomycosis who lack suggestive clinical symptoms. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 13 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Other | 3 | 23% |
Student > Bachelor | 2 | 15% |
Professor > Associate Professor | 2 | 15% |
Student > Ph. D. Student | 1 | 8% |
Researcher | 1 | 8% |
Other | 1 | 8% |
Unknown | 3 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 6 | 46% |
Nursing and Health Professions | 1 | 8% |
Biochemistry, Genetics and Molecular Biology | 1 | 8% |
Immunology and Microbiology | 1 | 8% |
Neuroscience | 1 | 8% |
Other | 0 | 0% |
Unknown | 3 | 23% |