| Title |
Neonatal Disruption of Serine Racemase Causes Schizophrenia-Like Behavioral Abnormalities in Adulthood: Clinical Rescue by D-Serine
|
|---|---|
| Published in |
PLOS ONE, April 2013
|
| DOI | 10.1371/journal.pone.0062438 |
| Pubmed ID | |
| Authors |
Hiroko Hagiwara, Masaomi Iyo, Kenji Hashimoto |
| Abstract |
D-Serine, an endogenous co-agonist of the N-methyl-D-aspartate (NMDA) receptor, is synthesized from L-serine by serine racemase (SRR). Given the role of D-serine in both neurodevelopment and the pathophysiology of schizophrenia, we examined whether neonatal disruption of D-serine synthesis by SRR inhibition could induce behavioral abnormalities relevant to schizophrenia, in later life. |
Mendeley readers
The data shown below were compiled from readership statistics for 64 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 2% |
| Unknown | 63 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 16 | 25% |
| Student > Ph. D. Student | 8 | 13% |
| Student > Bachelor | 8 | 13% |
| Student > Master | 7 | 11% |
| Other | 5 | 8% |
| Other | 8 | 13% |
| Unknown | 12 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 19 | 30% |
| Psychology | 9 | 14% |
| Medicine and Dentistry | 6 | 9% |
| Biochemistry, Genetics and Molecular Biology | 4 | 6% |
| Neuroscience | 3 | 5% |
| Other | 7 | 11% |
| Unknown | 16 | 25% |