| Title |
The Response of Human Macrophages to β-Glucans Depends on the Inflammatory Milieu
|
|---|---|
| Published in |
PLOS ONE, April 2013
|
| DOI | 10.1371/journal.pone.0062016 |
| Pubmed ID | |
| Authors |
Cristina Municio, Yolanda Alvarez, Olimpio Montero, Etzel Hugo, Mario Rodríguez, Esther Domingo, Sara Alonso, Nieves Fernández, Mariano Sánchez Crespo |
| Abstract |
β-glucans are fungal cell wall components that bind to the C-type lectin-like receptor dectin-1. Polymorphisms of dectin-1 gene are associated with susceptibility to invasive fungal infection and medically refractory ulcerative colitis. The purpose of this study has been addressing the response of human macrophages to β-glucans under different conditions mimicking the composition of the inflammatory milieu in view of the wide plasticity and large range of phenotypical changes showed by these cells, and the relevant role of dectin-1 in several pathophysiological conditions. |
Mendeley readers
The data shown below were compiled from readership statistics for 73 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Mexico | 1 | 1% |
| Spain | 1 | 1% |
| Australia | 1 | 1% |
| Brazil | 1 | 1% |
| Unknown | 69 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 22 | 30% |
| Student > Bachelor | 11 | 15% |
| Student > Master | 8 | 11% |
| Student > Ph. D. Student | 5 | 7% |
| Other | 3 | 4% |
| Other | 9 | 12% |
| Unknown | 15 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 19 | 26% |
| Immunology and Microbiology | 12 | 16% |
| Biochemistry, Genetics and Molecular Biology | 8 | 11% |
| Medicine and Dentistry | 6 | 8% |
| Veterinary Science and Veterinary Medicine | 3 | 4% |
| Other | 3 | 4% |
| Unknown | 22 | 30% |