| Title |
Knockdown of FRAT1 Expression by RNA Interference Inhibits Human Glioblastoma Cell Growth, Migration and Invasion
|
|---|---|
| Published in |
PLOS ONE, April 2013
|
| DOI | 10.1371/journal.pone.0061206 |
| Pubmed ID | |
| Authors |
Geng Guo, Dong Kuai, Sang Cai, Naizhao Xue, Yueting Liu, Jiehe Hao, Yimin Fan, Ji Jin, Xinggang Mao, Bolin Liu, Chengliang Zhong, Xiang Zhang, Yi Yue, Xiaodong Liu, Ning Ma, Yuhong Guo |
| Abstract |
FRAT1 positively regulates the Wnt/β-catenin signaling pathway by inhibiting GSK-3-mediated phosphorylation of β-catenin. It was originally characterized as a protein frequently rearranged in advanced T cell lymphoma, but has recently also been identified as a proto-oncogene involved in tumorigenesis. Our previous studies showed that FRAT1 was dramatically overexpressed in gliomas and its expression level was significantly increased along with clinicopathological grades. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Poland | 1 | 4% |
| Brazil | 1 | 4% |
| Unknown | 26 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 6 | 21% |
| Student > Bachelor | 4 | 14% |
| Student > Ph. D. Student | 3 | 11% |
| Professor > Associate Professor | 3 | 11% |
| Student > Master | 3 | 11% |
| Other | 5 | 18% |
| Unknown | 4 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 8 | 29% |
| Medicine and Dentistry | 6 | 21% |
| Agricultural and Biological Sciences | 4 | 14% |
| Physics and Astronomy | 2 | 7% |
| Psychology | 1 | 4% |
| Other | 1 | 4% |
| Unknown | 6 | 21% |