| Title |
Hunger in the Absence of Caloric Restriction Improves Cognition and Attenuates Alzheimer's Disease Pathology in a Mouse Model
|
|---|---|
| Published in |
PLOS ONE, April 2013
|
| DOI | 10.1371/journal.pone.0060437 |
| Pubmed ID | |
| Authors |
Emily J. Dhurandhar, David B. Allison, Thomas van Groen, Inga Kadish |
| Abstract |
It has been shown that caloric restriction (CR) delays aging and possibly delays the development of Alzheimer's disease (AD). We conjecture that the mechanism may involve interoceptive cues, rather than reduced energy intake per se. We determined that hunger alone, induced by a ghrelin agonist, reduces AD pathology and improves cognition in the APP-SwDI mouse model of AD. Long-term treatment with a ghrelin agonist was sufficient to improve the performance in the water maze. The treatment also reduced levels of amyloid beta (Aβ) and inflammation (microglial activation) at 6 months of age compared to the control group, similar to the effect of CR. Thus, a hunger-inducing drug attenuates AD pathology, in the absence of CR, and the neuroendocrine aspects of hunger also prevent age-related cognitive decline. |
X Demographics
The data shown below were collected from the profiles of 32 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 5 | 16% |
| United States | 4 | 13% |
| Brazil | 2 | 6% |
| Netherlands | 2 | 6% |
| Australia | 1 | 3% |
| United Arab Emirates | 1 | 3% |
| Chile | 1 | 3% |
| Mexico | 1 | 3% |
| Finland | 1 | 3% |
| Other | 0 | 0% |
| Unknown | 14 | 44% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 19 | 59% |
| Scientists | 9 | 28% |
| Science communicators (journalists, bloggers, editors) | 2 | 6% |
| Practitioners (doctors, other healthcare professionals) | 2 | 6% |
Mendeley readers
The data shown below were compiled from readership statistics for 132 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 2% |
| Japan | 2 | 2% |
| Portugal | 1 | <1% |
| Canada | 1 | <1% |
| Netherlands | 1 | <1% |
| United Kingdom | 1 | <1% |
| Denmark | 1 | <1% |
| Unknown | 122 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 22 | 17% |
| Researcher | 21 | 16% |
| Student > Bachelor | 18 | 14% |
| Student > Master | 13 | 10% |
| Other | 10 | 8% |
| Other | 23 | 17% |
| Unknown | 25 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 27 | 20% |
| Medicine and Dentistry | 22 | 17% |
| Psychology | 14 | 11% |
| Neuroscience | 11 | 8% |
| Nursing and Health Professions | 7 | 5% |
| Other | 20 | 15% |
| Unknown | 31 | 23% |