Title |
Tissue Inhibitor of Metalloproteinase 1 Is Preferentially Expressed in Th1 and Th17 T-Helper Cell Subsets and Is a Direct Stat Target Gene
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Published in |
PLOS ONE, March 2013
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DOI | 10.1371/journal.pone.0059367 |
Pubmed ID | |
Authors |
Adewole Adamson, Kamran Ghoreschi, Matthew Rittler, Qian Chen, Hong-Wei Sun, Golnaz Vahedi, Yuka Kanno, William G. Stetler-Stevenson, John J. O’Shea, Arian Laurence |
Abstract |
CD4(+) T helper (Th) cells differentiate into distinct effector subsets that are critical for host defense, but are also implicated in the pathogenesis of autoimmune disorders. Thelper17 (Th17) cells in particular are emerging as important drivers of multiple diseases including psoriasis, spondyloarthropathy and multiple sclerosis. To gain insight into the function of Th17 cells, we performed transcriptional profiling in hopes of elucidating products not previously recognized as being functionally relevant in these T cells. Herein, we demonstrate that tissue inhibitor of metalloproteinase 1 (TIMP1), a secreted protein with pleiotropic effects on cellular growth, survival and integrity of the extracellular matrix, is preferentially produced by Th17 and Th1 cells. We further show that Th1 and Th17 cell TIMP1 regulation follows separate mechanisms with a requirement for STAT4 in the former and STAT3 in the latter. Finally, we demonstrate that when restricted to T cells, expression of TIMP1 promotes neuropathology in experimental allergic encephalomyelitis. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 1 | 2% |
Unknown | 51 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 9 | 17% |
Researcher | 8 | 15% |
Professor > Associate Professor | 7 | 13% |
Student > Ph. D. Student | 6 | 12% |
Student > Postgraduate | 3 | 6% |
Other | 8 | 15% |
Unknown | 11 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 14 | 27% |
Biochemistry, Genetics and Molecular Biology | 8 | 15% |
Immunology and Microbiology | 7 | 13% |
Agricultural and Biological Sciences | 6 | 12% |
Psychology | 1 | 2% |
Other | 2 | 4% |
Unknown | 14 | 27% |