Title |
Multiple Single-Cell Genomes Provide Insight into Functions of Uncultured Deltaproteobacteria in the Human Oral Cavity
|
---|---|
Published in |
PLOS ONE, March 2013
|
DOI | 10.1371/journal.pone.0059361 |
Pubmed ID | |
Authors |
Alisha G. Campbell, James H. Campbell, Patrick Schwientek, Tanja Woyke, Alexander Sczyrba, Steve Allman, Clifford J. Beall, Ann Griffen, Eugene Leys, Mircea Podar |
Abstract |
Despite a long history of investigation, many bacteria associated with the human oral cavity have yet to be cultured. Studies that correlate the presence or abundance of uncultured species with oral health or disease highlight the importance of these community members. Thus, we sequenced several single-cell genomic amplicons from Desulfobulbus and Desulfovibrio (class Deltaproteobacteria) to better understand their function within the human oral community and their association with periodontitis, as well as other systemic diseases. Genomic data from oral Desulfobulbus and Desulfovibrio species were compared to other available deltaproteobacterial genomes, including from a subset of host-associated species. While both groups share a large number of genes with other environmental Deltaproteobacteria genomes, they encode a wide array of unique genes that appear to function in survival in a host environment. Many of these genes are similar to virulence and host adaptation factors of known human pathogens, suggesting that the oral Deltaproteobacteria have the potential to play a role in the etiology of periodontal disease. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 33% |
Unknown | 4 | 67% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 4 | 67% |
Scientists | 2 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 2% |
Slovenia | 1 | 2% |
Saudi Arabia | 1 | 2% |
Unknown | 54 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 13 | 23% |
Researcher | 9 | 16% |
Student > Master | 6 | 11% |
Student > Doctoral Student | 4 | 7% |
Professor > Associate Professor | 4 | 7% |
Other | 9 | 16% |
Unknown | 12 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 18 | 32% |
Biochemistry, Genetics and Molecular Biology | 9 | 16% |
Immunology and Microbiology | 5 | 9% |
Medicine and Dentistry | 4 | 7% |
Environmental Science | 2 | 4% |
Other | 6 | 11% |
Unknown | 13 | 23% |