Report for: Experimental Evidence for the Involvement of PDLIM5 in Mood Disorders in Hetero Knockout Mice

Title	Experimental Evidence for the Involvement of PDLIM5 in Mood Disorders in Hetero Knockout Mice
Published in	PLOS ONE, April 2013
DOI	10.1371/journal.pone.0059320
Pubmed ID	23593136
Authors	Yasue Horiuchi, Maya Ishikawa, Nobuko Kaito, Yoshimi Iijima, Yoshiko Tanabe, Hiroki Ishiguro, Tadao Arinami
Abstract	Reports indicate that PDLIM5 is involved in mood disorders. The PDLIM5 (PDZ and LIM domain 5) gene has been genetically associated with mood disorders; it's expression is upregulated in the postmortem brains of patients with bipolar disorder and downregulated in the peripheral lymphocytes of patients with major depression. Acute and chronic methamphetamine (METH) administration may model mania and the evolution of mania into psychotic mania or schizophrenia-like behavioral changes, respectively.

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Other	11	24%
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