Title |
Clozapine-Induced Mitochondria Alterations and Inflammation in Brain and Insulin-Responsive Cells
|
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Published in |
PLOS ONE, March 2013
|
DOI | 10.1371/journal.pone.0059012 |
Pubmed ID | |
Authors |
Verόnica Contreras-Shannon, Dylan L. Heart, R. Madelaine Paredes, Erica Navaira, Gabriel Catano, Shivani Kaushal Maffi, Consuelo Walss-Bass |
Abstract |
Metabolic syndrome (MetS) is a constellation of factors including abdominal obesity, hyperglycemia, dyslipidemias, and hypertension that increase morbidity and mortality from diabetes and cardiovascular diseases and affects more than a third of the population in the US. Clozapine, an atypical antipsychotic used for the treatment of schizophrenia, has been found to cause drug-induced metabolic syndrome (DIMS) and may be a useful tool for studying cellular and molecular changes associated with MetS and DIMS. Mitochondria dysfunction, oxidative stress and inflammation are mechanisms proposed for the development of clozapine-related DIMS. In this study, the effects of clozapine on mitochondrial function and inflammation in insulin responsive and obesity-associated cultured cell lines were examined. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 4 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | <1% |
Turkey | 1 | <1% |
Denmark | 1 | <1% |
Brazil | 1 | <1% |
Unknown | 119 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 23 | 19% |
Student > Master | 13 | 11% |
Student > Bachelor | 12 | 10% |
Student > Ph. D. Student | 11 | 9% |
Student > Doctoral Student | 9 | 7% |
Other | 26 | 21% |
Unknown | 29 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 29 | 24% |
Agricultural and Biological Sciences | 13 | 11% |
Pharmacology, Toxicology and Pharmaceutical Science | 8 | 7% |
Biochemistry, Genetics and Molecular Biology | 7 | 6% |
Psychology | 7 | 6% |
Other | 14 | 11% |
Unknown | 45 | 37% |