Title |
Incorporating DNA Sequencing into Current Prenatal Screening Practice for Down's Syndrome
|
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Published in |
PLOS ONE, March 2013
|
DOI | 10.1371/journal.pone.0058732 |
Pubmed ID | |
Authors |
Nicholas J. Wald, Jonathan P. Bestwick |
Abstract |
Prenatal screening for Down's syndrome is performed using biochemical and ultrasound markers measured in early pregnancy such as the Integrated test using first and second trimester markers. Recently, DNA sequencing methods have been introduced on free DNA in maternal plasma, yielding a high screening performance. These methods are expensive and there is a test failure rate. We determined the screening performance of merging the Integrated test with the newer DNA techniques in a protocol that substantially reduces the cost compared with universal DNA testing and still achieves high screening performance with no test failures. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 50% |
United States | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 49 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 2% |
France | 1 | 2% |
Unknown | 47 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 13 | 27% |
Other | 7 | 14% |
Student > Ph. D. Student | 7 | 14% |
Student > Master | 6 | 12% |
Student > Doctoral Student | 3 | 6% |
Other | 9 | 18% |
Unknown | 4 | 8% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 17 | 35% |
Agricultural and Biological Sciences | 12 | 24% |
Biochemistry, Genetics and Molecular Biology | 5 | 10% |
Nursing and Health Professions | 3 | 6% |
Social Sciences | 2 | 4% |
Other | 5 | 10% |
Unknown | 5 | 10% |