| Title |
Salmonella Infection Upregulates the Leaky Protein Claudin-2 in Intestinal Epithelial Cells
|
|---|---|
| Published in |
PLOS ONE, March 2013
|
| DOI | 10.1371/journal.pone.0058606 |
| Pubmed ID | |
| Authors |
Yong-guo Zhang, Shaoping Wu, Yinglin Xia, Jun Sun |
| Abstract |
Tight junctions seal the space between adjacent epithelial cells. Mounting evidence suggests that tight junction proteins play a key role in the pathogenesis of human disease. Claudin is a member of the tight junction protein family, which has 24 members in humans. To regulate cellular function, claudins interact structurally and functionally with membrane and scaffolding proteins via their cytoplasmic domain. In particular, claudin-2 is known to be a leaky protein that contributes to inflammatory bowel disease and colon cancer. However, the involvement of claudin-2 in bacterial infection in the intestine remains unknown. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Scientists | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 65 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | 2% |
| Brazil | 1 | 2% |
| Unknown | 63 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 14 | 22% |
| Researcher | 10 | 15% |
| Student > Bachelor | 8 | 12% |
| Student > Doctoral Student | 6 | 9% |
| Student > Master | 6 | 9% |
| Other | 9 | 14% |
| Unknown | 12 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 18 | 28% |
| Biochemistry, Genetics and Molecular Biology | 8 | 12% |
| Immunology and Microbiology | 8 | 12% |
| Medicine and Dentistry | 5 | 8% |
| Veterinary Science and Veterinary Medicine | 4 | 6% |
| Other | 7 | 11% |
| Unknown | 15 | 23% |