Title |
Lamin A/C Haploinsufficiency Modulates the Differentiation Potential of Mouse Embryonic Stem Cells
|
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Published in |
PLOS ONE, February 2013
|
DOI | 10.1371/journal.pone.0057891 |
Pubmed ID | |
Authors |
Poonam Sehgal, Pankaj Chaturvedi, R. Ileng Kumaran, Satish Kumar, Veena K. Parnaik |
Abstract |
Lamins are structural proteins that are the major determinants of nuclear architecture and play important roles in various nuclear functions including gene regulation and cell differentiation. Mutations in the human lamin A gene cause a spectrum of genetic diseases that affect specific tissues. Most available mouse models for laminopathies recapitulate disease symptoms for muscle diseases and progerias. However, loss of human lamin A/C also has highly deleterious effects on fetal development. Hence it is important to understand the impact of lamin A/C expression levels on embryonic differentiation pathways. |
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