| Title |
Antipurinergic Therapy Corrects the Autism-Like Features in the Poly(IC) Mouse Model
|
|---|---|
| Published in |
PLOS ONE, March 2013
|
| DOI | 10.1371/journal.pone.0057380 |
| Pubmed ID | |
| Authors |
Robert K. Naviaux, Zarazuela Zolkipli, Lin Wang, Tomohiro Nakayama, Jane C. Naviaux, Thuy P. Le, Michael A. Schuchbauer, Mihael Rogac, Qingbo Tang, Laura L. Dugan, Susan B. Powell |
| Abstract |
Autism spectrum disorders (ASDs) are caused by both genetic and environmental factors. Mitochondria act to connect genes and environment by regulating gene-encoded metabolic networks according to changes in the chemistry of the cell and its environment. Mitochondrial ATP and other metabolites are mitokines-signaling molecules made in mitochondria-that undergo regulated release from cells to communicate cellular health and danger to neighboring cells via purinergic signaling. The role of purinergic signaling has not yet been explored in autism spectrum disorders. |
X Demographics
The data shown below were collected from the profiles of 21 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 8 | 38% |
| Venezuela, Bolivarian Republic of | 1 | 5% |
| Korea, Republic of | 1 | 5% |
| Spain | 1 | 5% |
| Canada | 1 | 5% |
| United Kingdom | 1 | 5% |
| Unknown | 8 | 38% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 19 | 90% |
| Practitioners (doctors, other healthcare professionals) | 1 | 5% |
| Scientists | 1 | 5% |
Mendeley readers
The data shown below were compiled from readership statistics for 240 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 2% |
| Chile | 1 | <1% |
| Italy | 1 | <1% |
| Brazil | 1 | <1% |
| Unknown | 232 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 46 | 19% |
| Researcher | 40 | 17% |
| Student > Bachelor | 35 | 15% |
| Student > Master | 21 | 9% |
| Student > Doctoral Student | 19 | 8% |
| Other | 49 | 20% |
| Unknown | 30 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 55 | 23% |
| Neuroscience | 36 | 15% |
| Medicine and Dentistry | 35 | 15% |
| Biochemistry, Genetics and Molecular Biology | 26 | 11% |
| Psychology | 19 | 8% |
| Other | 26 | 11% |
| Unknown | 43 | 18% |