| Title |
Carboxylesterase 1 Gene Duplication and mRNA Expression in Adipose Tissue Are Linked to Obesity and Metabolic Function
|
|---|---|
| Published in |
PLOS ONE, February 2013
|
| DOI | 10.1371/journal.pone.0056861 |
| Pubmed ID | |
| Authors |
Martin Friedrichsen, Pernille Poulsen, Jørgen Wojtaszewski, Peter Riis Hansen, Allan Vaag, Henrik Berg Rasmussen |
| Abstract |
CONTEXT AND AIMS: Carboxylesterase 1 (CES1) appears to play an important role in the control of the metabolism of triglycerides and cholesterol in adipocytes and other cell types including hepatocytes. Therefore, it is relevant to gain insights into the genetic versus non-genetic mechanisms involved in the control of CES1 mRNA expression. Here, we investigated CES1 mRNA expression level in adipose tissue and its association with measures of adiposity and metabolic function in a population of elderly twins. Furthermore, the heritability of CES1 mRNA expression level in adipose tissue and the effect of CES1 gene duplication were assessed. |
Mendeley readers
The data shown below were compiled from readership statistics for 36 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 36 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 9 | 25% |
| Student > Ph. D. Student | 5 | 14% |
| Researcher | 4 | 11% |
| Unspecified | 2 | 6% |
| Student > Master | 2 | 6% |
| Other | 4 | 11% |
| Unknown | 10 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 8 | 22% |
| Agricultural and Biological Sciences | 5 | 14% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 8% |
| Biochemistry, Genetics and Molecular Biology | 3 | 8% |
| Unspecified | 2 | 6% |
| Other | 4 | 11% |
| Unknown | 11 | 31% |