| Title |
Jejunal Proteins Secreted by db/db Mice or Insulin-Resistant Humans Impair the Insulin Signaling and Determine Insulin Resistance
|
|---|---|
| Published in |
PLOS ONE, February 2013
|
| DOI | 10.1371/journal.pone.0056258 |
| Pubmed ID | |
| Authors |
Serenella Salinari, Cyrille Debard, Alessandro Bertuzzi, Christine Durand, Paul Zimmet, Hubert Vidal, Geltrude Mingrone |
| Abstract |
Two recent studies demonstrated that bariatric surgery induced remission of type 2 diabetes very soon after surgery and far too early to be attributed to weight loss. In this study, we sought to explore the mechanism/s of this phenomenon by testing the effects of proteins from the duodenum-jejunum conditioned-medium (CM) of db/db or Swiss mice on glucose uptake in vivo in Swiss mice and in vitro in both Swiss mice soleus and L6 cells. We studied the effect of sera and CM proteins from insulin resistant (IR) and insulin-sensitive subjects on insulin signaling in human myoblasts. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Denmark | 1 | 50% |
| Australia | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 50% |
| Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 54 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 2% |
| Unknown | 53 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 17 | 31% |
| Student > Bachelor | 8 | 15% |
| Student > Ph. D. Student | 8 | 15% |
| Other | 6 | 11% |
| Student > Postgraduate | 5 | 9% |
| Other | 5 | 9% |
| Unknown | 5 | 9% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 25 | 46% |
| Agricultural and Biological Sciences | 12 | 22% |
| Biochemistry, Genetics and Molecular Biology | 4 | 7% |
| Engineering | 3 | 6% |
| Unspecified | 1 | 2% |
| Other | 3 | 6% |
| Unknown | 6 | 11% |