| Title |
Computational Analysis of KRAS Mutations: Implications for Different Effects on the KRAS p.G12D and p.G13D Mutations
|
|---|---|
| Published in |
PLOS ONE, February 2013
|
| DOI | 10.1371/journal.pone.0055793 |
| Pubmed ID | |
| Authors |
Chih-Chieh Chen, Tze-Kiong Er, Yen-Yi Liu, Jenn-Kang Hwang, Maria Jesus Barrio, Maximiliano Rodrigo, Enrique Garcia-Toro, Marta Herreros-Villanueva |
| Abstract |
The issue of whether patients diagnosed with metastatic colorectal cancer who harbor KRAS codon 13 mutations could benefit from the addition of anti-epidermal growth factor receptor therapy remains under debate. The aim of the current study was to perform computational analysis to investigate the structural implications of the underlying mutations caused by c.38G>A (p.G13D) on protein conformation. |
Mendeley readers
The data shown below were compiled from readership statistics for 140 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 1% |
| Denmark | 1 | <1% |
| South Africa | 1 | <1% |
| Unknown | 136 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 28 | 20% |
| Student > Ph. D. Student | 27 | 19% |
| Student > Master | 21 | 15% |
| Student > Bachelor | 13 | 9% |
| Other | 9 | 6% |
| Other | 12 | 9% |
| Unknown | 30 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 34 | 24% |
| Agricultural and Biological Sciences | 31 | 22% |
| Medicine and Dentistry | 14 | 10% |
| Chemistry | 13 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 4% |
| Other | 6 | 4% |
| Unknown | 36 | 26% |