| Title |
Genetic and Pharmacological Modifications of Thrombin Formation in Apolipoprotein E-deficient Mice Determine Atherosclerosis Severity and Atherothrombosis Onset in a Neutrophil-Dependent Manner
|
|---|---|
| Published in |
PLOS ONE, February 2013
|
| DOI | 10.1371/journal.pone.0055784 |
| Pubmed ID | |
| Authors |
Julian I. Borissoff, Jeroen J. T. Otten, Sylvia Heeneman, Peter Leenders, René van Oerle, Oliver Soehnlein, Sarah T. B. G. Loubele, Karly Hamulyák, Tilman M. Hackeng, Mat J. A. P. Daemen, Jay L. Degen, Hartmut Weiler, Charles T. Esmon, Joanne van Ryn, Erik A. L. Biessen, Henri M. H. Spronk, Hugo ten Cate |
| Abstract |
Variations in the blood coagulation activity, determined genetically or by medication, may alter atherosclerotic plaque progression, by influencing pleiotropic effects of coagulation proteases. Published experimental studies have yielded contradictory findings on the role of hypercoagulability in atherogenesis. We therefore sought to address this matter by extensively investigating the in vivo significance of genetic alterations and pharmacologic inhibition of thrombin formation for the onset and progression of atherosclerosis, and plaque phenotype determination. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 57 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 2% |
| United States | 1 | 2% |
| Netherlands | 1 | 2% |
| Unknown | 54 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 11 | 19% |
| Researcher | 10 | 18% |
| Student > Master | 8 | 14% |
| Student > Bachelor | 7 | 12% |
| Professor > Associate Professor | 5 | 9% |
| Other | 8 | 14% |
| Unknown | 8 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 17 | 30% |
| Medicine and Dentistry | 15 | 26% |
| Biochemistry, Genetics and Molecular Biology | 9 | 16% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 5% |
| Unspecified | 1 | 2% |
| Other | 3 | 5% |
| Unknown | 9 | 16% |