| Title |
Candidate Sequence Variants and Fetal Hemoglobin in Children with Sickle Cell Disease Treated with Hydroxyurea
|
|---|---|
| Published in |
PLOS ONE, February 2013
|
| DOI | 10.1371/journal.pone.0055709 |
| Pubmed ID | |
| Authors |
Nancy S. Green, Katherine L. Ender, Farzana Pashankar, Catherine Driscoll, Patricia J. Giardina, Craig A. Mullen, Lorraine N. Clark, Deepa Manwani, Jennifer Crotty, Sergey Kisselev, Kathleen A. Neville, Carolyn Hoppe, Sandra Barral |
| Abstract |
Fetal hemoglobin level is a heritable complex trait that strongly correlates swith the clinical severity of sickle cell disease. Only few genetic loci have been identified as robustly associated with fetal hemoglobin in patients with sickle cell disease, primarily adults. The sole approved pharmacologic therapy for this disease is hydroxyurea, with effects largely attributable to induction of fetal hemoglobin. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 70 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Italy | 1 | 1% |
| Canada | 1 | 1% |
| Unknown | 68 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 15 | 21% |
| Researcher | 8 | 11% |
| Student > Master | 8 | 11% |
| Other | 6 | 9% |
| Professor | 4 | 6% |
| Other | 17 | 24% |
| Unknown | 12 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 18 | 26% |
| Biochemistry, Genetics and Molecular Biology | 16 | 23% |
| Agricultural and Biological Sciences | 13 | 19% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 3% |
| Nursing and Health Professions | 2 | 3% |
| Other | 4 | 6% |
| Unknown | 15 | 21% |