| Title |
Fermentation of Propionibacterium acnes, a Commensal Bacterium in the Human Skin Microbiome, as Skin Probiotics against Methicillin-Resistant Staphylococcus aureus
|
|---|---|
| Published in |
PLOS ONE, February 2013
|
| DOI | 10.1371/journal.pone.0055380 |
| Pubmed ID | |
| Authors |
Muya Shu, Yanhan Wang, Jinghua Yu, Sherwin Kuo, Alvin Coda, Yong Jiang, Richard L. Gallo, Chun-Ming Huang |
| Abstract |
Bacterial interference creates an ecological competition between commensal and pathogenic bacteria. Through fermentation of milk with gut-friendly bacteria, yogurt is an excellent aid to balance the bacteriological ecosystem in the human intestine. Here, we demonstrate that fermentation of glycerol with Propionibacterium acnes (P. acnes), a skin commensal bacterium, can function as a skin probiotic for in vitro and in vivo growth suppression of USA300, the most prevalent community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA). We also promote the notion that inappropriate use of antibiotics may eliminate the skin commensals, making it more difficult to fight pathogen infection. This study warrants further investigation to better understand the role of fermentation of skin commensals in infectious disease and the importance of the human skin microbiome in skin health. |
X Demographics
The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 83% |
| Unknown | 1 | 17% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 50% |
| Scientists | 3 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 364 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | <1% |
| United States | 1 | <1% |
| Germany | 1 | <1% |
| France | 1 | <1% |
| Unknown | 360 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 58 | 16% |
| Student > Bachelor | 49 | 13% |
| Student > Ph. D. Student | 48 | 13% |
| Student > Master | 38 | 10% |
| Other | 24 | 7% |
| Other | 57 | 16% |
| Unknown | 90 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 81 | 22% |
| Medicine and Dentistry | 54 | 15% |
| Biochemistry, Genetics and Molecular Biology | 45 | 12% |
| Immunology and Microbiology | 41 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 11 | 3% |
| Other | 37 | 10% |
| Unknown | 95 | 26% |