| Title |
MTN-001: Randomized Pharmacokinetic Cross-Over Study Comparing Tenofovir Vaginal Gel and Oral Tablets in Vaginal Tissue and Other Compartments
|
|---|---|
| Published in |
PLOS ONE, January 2013
|
| DOI | 10.1371/journal.pone.0055013 |
| Pubmed ID | |
| Authors |
Craig W. Hendrix, Beatrice A. Chen, Vijayanand Guddera, Craig Hoesley, Jessica Justman, Clemensia Nakabiito, Robert Salata, Lydia Soto-Torres, Karen Patterson, Alexandra M. Minnis, Sharavi Gandham, Kailazarid Gomez, Barbra A. Richardson, Namandje N. Bumpus |
| Abstract |
Oral and vaginal preparations of tenofovir as pre-exposure prophylaxis (PrEP) for human immunodeficiency virus (HIV) infection have demonstrated variable efficacy in men and women prompting assessment of variation in drug concentration as an explanation. Knowledge of tenofovir concentration and its active form, tenofovir diphosphate, at the putative vaginal and rectal site of action and its relationship to concentrations at multiple other anatomic locations may provide key information for both interpreting PrEP study outcomes and planning future PrEP drug development. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 33% |
| Scientists | 1 | 33% |
| Members of the public | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 143 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Malaysia | 1 | <1% |
| United States | 1 | <1% |
| Czechia | 1 | <1% |
| Brazil | 1 | <1% |
| Unknown | 139 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 27 | 19% |
| Researcher | 25 | 17% |
| Student > Ph. D. Student | 18 | 13% |
| Student > Bachelor | 17 | 12% |
| Student > Doctoral Student | 9 | 6% |
| Other | 25 | 17% |
| Unknown | 22 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 48 | 34% |
| Pharmacology, Toxicology and Pharmaceutical Science | 15 | 10% |
| Agricultural and Biological Sciences | 11 | 8% |
| Nursing and Health Professions | 9 | 6% |
| Biochemistry, Genetics and Molecular Biology | 6 | 4% |
| Other | 24 | 17% |
| Unknown | 30 | 21% |