| Title |
Local Delivery of Cannabinoid-Loaded Microparticles Inhibits Tumor Growth in a Murine Xenograft Model of Glioblastoma Multiforme
|
|---|---|
| Published in |
PLOS ONE, January 2013
|
| DOI | 10.1371/journal.pone.0054795 |
| Pubmed ID | |
| Authors |
Dolores Hernán Pérez de la Ossa, Mar Lorente, Maria Esther Gil-Alegre, Sofía Torres, Elena García-Taboada, María del Rosario Aberturas, Jesús Molpeceres, Guillermo Velasco, Ana Isabel Torres-Suárez |
| Abstract |
Cannabinoids, the active components of marijuana and their derivatives, are currently investigated due to their potential therapeutic application for the management of many different diseases, including cancer. Specifically, Δ(9)-Tetrahydrocannabinol (THC) and Cannabidiol (CBD) - the two major ingredients of marijuana - have been shown to inhibit tumor growth in a number of animal models of cancer, including glioma. Although there are several pharmaceutical preparations that permit the oral administration of THC or its analogue nabilone or the oromucosal delivery of a THC- and CBD-enriched cannabis extract, the systemic administration of cannabinoids has several limitations in part derived from the high lipophilicity exhibited by these compounds. In this work we analyzed CBD- and THC-loaded poly-ε-caprolactone microparticles as an alternative delivery system for long-term cannabinoid administration in a murine xenograft model of glioma. In vitro characterization of THC- and CBD-loaded microparticles showed that this method of microencapsulation facilitates a sustained release of the two cannabinoids for several days. Local administration of THC-, CBD- or a mixture (1:1 w:w) of THC- and CBD-loaded microparticles every 5 days to mice bearing glioma xenografts reduced tumour growth with the same efficacy than a daily local administration of the equivalent amount of those cannabinoids in solution. Moreover, treatment with cannabinoid-loaded microparticles enhanced apoptosis and decreased cell proliferation and angiogenesis in these tumours. Our findings support that THC- and CBD-loaded microparticles could be used as an alternative method of cannabinoid delivery in anticancer therapies. |
X Demographics
The data shown below were collected from the profiles of 46 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 17 | 37% |
| Canada | 2 | 4% |
| Georgia | 2 | 4% |
| United Kingdom | 1 | 2% |
| Belgium | 1 | 2% |
| Israel | 1 | 2% |
| Montenegro | 1 | 2% |
| South Africa | 1 | 2% |
| Italy | 1 | 2% |
| Other | 1 | 2% |
| Unknown | 18 | 39% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 38 | 83% |
| Practitioners (doctors, other healthcare professionals) | 3 | 7% |
| Science communicators (journalists, bloggers, editors) | 3 | 7% |
| Scientists | 1 | 2% |
| Unknown | 1 | 2% |
Mendeley readers
The data shown below were compiled from readership statistics for 226 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 2% |
| United Kingdom | 3 | 1% |
| Brazil | 2 | <1% |
| India | 1 | <1% |
| Russia | 1 | <1% |
| France | 1 | <1% |
| Unknown | 213 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 40 | 18% |
| Student > Ph. D. Student | 34 | 15% |
| Student > Master | 24 | 11% |
| Student > Bachelor | 23 | 10% |
| Other | 13 | 6% |
| Other | 40 | 18% |
| Unknown | 52 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 37 | 16% |
| Agricultural and Biological Sciences | 28 | 12% |
| Biochemistry, Genetics and Molecular Biology | 21 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 20 | 9% |
| Engineering | 7 | 3% |
| Other | 48 | 21% |
| Unknown | 65 | 29% |