Report for: High-Resolution Analysis and Functional Mapping of Cleavage Sites and Substrate Proteins of Furin in the Human Proteome

Title	High-Resolution Analysis and Functional Mapping of Cleavage Sites and Substrate Proteins of Furin in the Human Proteome
Published in	PLOS ONE, January 2013
DOI	10.1371/journal.pone.0054290
Pubmed ID	23335997
Authors	Sergey A. Shiryaev, Andrei V. Chernov, Vladislav S. Golubkov, Elliot R. Thomsen, Eugene Chudin, Mark S. Chee, Igor A. Kozlov, Alex Y. Strongin, Piotr Cieplak
Abstract	There is a growing appreciation of the role of proteolytic processes in human health and disease, but tools for analysis of such processes on a proteome-wide scale are limited. Furin is a ubiquitous proprotein convertase that cleaves after basic residues and transforms secretory proproteins into biologically active proteins. Despite this important role, many furin substrates remain unknown in the human proteome.

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