| Title |
MudPIT Profiling Reveals a Link between Anaerobic Metabolism and the Alkaline Adaptive Response of Listeria monocytogenes EGD-e
|
|---|---|
| Published in |
PLOS ONE, January 2013
|
| DOI | 10.1371/journal.pone.0054157 |
| Pubmed ID | |
| Authors |
Rolf E. Nilsson, Tom Ross, John P. Bowman, Margaret L. Britz |
| Abstract |
Listeria monocytogenes is a foodborne human pathogen capable of causing life-threatening disease in susceptible populations. Previous proteomic analysis we performed demonstrated that different strains of L. monocytogenes initiate a stringent response when subjected to alkaline growth conditions. Here, using multidimensional protein identification technology (MudPIT), we show that in L. monocytogenes EGD-e this response involves an energy shift to anaerobic pathways in response to the extracellular pH environment. Importantly we show that this supports a reduction in relative lag time following an abrupt transition to low oxygen tension culture conditions. This has important implications for the packaging of fresh and ready-to-eat foods under reduced oxygen conditions in environments where potential exists for alkaline adaptation. |
Mendeley readers
The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 23 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 4 | 17% |
| Researcher | 4 | 17% |
| Other | 2 | 9% |
| Student > Postgraduate | 2 | 9% |
| Student > Master | 2 | 9% |
| Other | 4 | 17% |
| Unknown | 5 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 11 | 48% |
| Immunology and Microbiology | 4 | 17% |
| Economics, Econometrics and Finance | 1 | 4% |
| Business, Management and Accounting | 1 | 4% |
| Unknown | 6 | 26% |