| Title |
Combining Functional and Structural Genomics to Sample the Essential Burkholderia Structome
|
|---|---|
| Published in |
PLOS ONE, January 2013
|
| DOI | 10.1371/journal.pone.0053851 |
| Pubmed ID | |
| Authors |
Loren Baugh, Larry A. Gallagher, Rapatbhorn Patrapuvich, Matthew C. Clifton, Anna S. Gardberg, Thomas E. Edwards, Brianna Armour, Darren W. Begley, Shellie H. Dieterich, David M. Dranow, Jan Abendroth, James W. Fairman, David Fox, Bart L. Staker, Isabelle Phan, Angela Gillespie, Ryan Choi, Steve Nakazawa-Hewitt, Mary Trang Nguyen, Alberto Napuli, Lynn Barrett, Garry W. Buchko, Robin Stacy, Peter J. Myler, Lance J. Stewart, Colin Manoil, Wesley C. Van Voorhis |
| Abstract |
The genus Burkholderia includes pathogenic gram-negative bacteria that cause melioidosis, glanders, and pulmonary infections of patients with cancer and cystic fibrosis. Drug resistance has made development of new antimicrobials critical. Many approaches to discovering new antimicrobials, such as structure-based drug design and whole cell phenotypic screens followed by lead refinement, require high-resolution structures of proteins essential to the parasite. |
X Demographics
The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 50% |
| Panama | 2 | 33% |
| Unknown | 1 | 17% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 67% |
| Practitioners (doctors, other healthcare professionals) | 1 | 17% |
| Scientists | 1 | 17% |
Mendeley readers
The data shown below were compiled from readership statistics for 151 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 2 | 1% |
| United States | 2 | 1% |
| Denmark | 2 | 1% |
| Mexico | 2 | 1% |
| Italy | 1 | <1% |
| Brazil | 1 | <1% |
| Chile | 1 | <1% |
| Argentina | 1 | <1% |
| Unknown | 139 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 36 | 24% |
| Student > Ph. D. Student | 35 | 23% |
| Student > Bachelor | 15 | 10% |
| Student > Master | 14 | 9% |
| Student > Postgraduate | 7 | 5% |
| Other | 21 | 14% |
| Unknown | 23 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 53 | 35% |
| Biochemistry, Genetics and Molecular Biology | 43 | 28% |
| Immunology and Microbiology | 11 | 7% |
| Medicine and Dentistry | 5 | 3% |
| Chemistry | 4 | 3% |
| Other | 13 | 9% |
| Unknown | 22 | 15% |