| Title |
The CD3 versus CD7 Plot in Multicolor Flow Cytometry Reflects Progression of Disease Stage in Patients Infected with HTLV-I
|
|---|---|
| Published in |
PLOS ONE, January 2013
|
| DOI | 10.1371/journal.pone.0053728 |
| Pubmed ID | |
| Authors |
Seiichiro Kobayashi, Yamin Tian, Nobuhiro Ohno, Koichiro Yuji, Tomohiro Ishigaki, Masamichi Isobe, Mayuko Tsuda, Naoki Oyaizu, Eri Watanabe, Nobukazu Watanabe, Kenzaburo Tani, Arinobu Tojo, Kaoru Uchimaru |
| Abstract |
In a recent study to purify adult T-cell leukemia-lymphoma (ATL) cells from acute-type patients by flow cytometry, three subpopulations were observed in a CD3 versus CD7 plot (H: CD3(high)CD7(high); D: CD3(dim)CD7(dim); L: CD3(dim)CD7(low)). The majority of leukemia cells were enriched in the L subpopulation and the same clone was included in the D and L subpopulations, suggesting clonal evolution. In this study, we analyzed patients with indolent-type ATL and human T-cell leukemia virus type I (HTLV-I) asymptomatic carriers (ACs) to see whether the CD3 versus CD7 profile reflected progression in the properties of HTLV-I-infected cells. |
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 2 | 6% |
| United States | 1 | 3% |
| Brazil | 1 | 3% |
| Unknown | 27 | 87% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 7 | 23% |
| Student > Master | 4 | 13% |
| Student > Postgraduate | 3 | 10% |
| Professor > Associate Professor | 3 | 10% |
| Other | 2 | 6% |
| Other | 6 | 19% |
| Unknown | 6 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 8 | 26% |
| Medicine and Dentistry | 7 | 23% |
| Biochemistry, Genetics and Molecular Biology | 4 | 13% |
| Immunology and Microbiology | 3 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 3% |
| Other | 2 | 6% |
| Unknown | 6 | 19% |