| Title |
Understanding the Role of Keratins 8 and 18 in Neoplastic Potential of Breast Cancer Derived Cell Lines
|
|---|---|
| Published in |
PLOS ONE, January 2013
|
| DOI | 10.1371/journal.pone.0053532 |
| Pubmed ID | |
| Authors |
Sapna V. Iyer, Prerana P. Dange, Hunain Alam, Sharada S. Sawant, Arvind D. Ingle, Anita M. Borges, Neelam V. Shirsat, Sorab N. Dalal, Milind M. Vaidya |
| Abstract |
Breast cancer is a complex disease which cannot be defined merely by clinical parameters like lymph node involvement and histological grade, or by routinely used biomarkers like estrogen receptor (ER), progesterone receptor (PGR) and epidermal growth factor receptor 2 (HER2) in diagnosis and prognosis. Breast cancer originates from the epithelial cells. Keratins (K) are cytoplasmic intermediate filament proteins of epithelial cells and changes in the expression pattern of keratins have been seen during malignant transformation in the breast. Expression of the K8/18 pair is seen in the luminal cells of the breast epithelium, and its role in prognostication of breast cancer is not well understood. |
Mendeley readers
The data shown below were compiled from readership statistics for 88 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Finland | 1 | 1% |
| Malaysia | 1 | 1% |
| India | 1 | 1% |
| Unknown | 85 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 19 | 22% |
| Student > Ph. D. Student | 16 | 18% |
| Student > Master | 10 | 11% |
| Researcher | 6 | 7% |
| Professor | 5 | 6% |
| Other | 17 | 19% |
| Unknown | 15 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 24 | 27% |
| Biochemistry, Genetics and Molecular Biology | 21 | 24% |
| Medicine and Dentistry | 10 | 11% |
| Unspecified | 2 | 2% |
| Physics and Astronomy | 2 | 2% |
| Other | 12 | 14% |
| Unknown | 17 | 19% |