| Title |
Alpha-Tocopheryl Succinate Inhibits Autophagic Survival of Prostate Cancer Cells Induced by Vitamin K3 and Ascorbate to Trigger Cell Death
|
|---|---|
| Published in |
PLOS ONE, December 2012
|
| DOI | 10.1371/journal.pone.0052263 |
| Pubmed ID | |
| Authors |
Marco Tomasetti, Linda Nocchi, Jiri Neuzil, Jacob Goodwin, Maria Nguyen, Lanfeng Dong, Nicola Manzella, Sara Staffolani, Claudio Milanese, Beatrice Garrone, Renata Alleva, Battista Borghi, Lory Santarelli, Roberto Guerrieri |
| Abstract |
The redox-silent vitamin E analog α-tocopheryl succinate (α-TOS) was found to synergistically cooperate with vitamin K3 (VK3) plus ascorbic acid (AA) in the induction of cancer cell-selective apoptosis via a caspase-independent pathway. Here we investigated the molecular mechanism(s) underlying cell death induced in prostate cancer cells by α-TOS, VK3 and AA, and the potential use of targeted drug combination in the treatment of prostate cancer. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 28 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 5 | 18% |
| Student > Ph. D. Student | 4 | 14% |
| Lecturer > Senior Lecturer | 2 | 7% |
| Student > Doctoral Student | 2 | 7% |
| Professor | 2 | 7% |
| Other | 8 | 29% |
| Unknown | 5 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 6 | 21% |
| Biochemistry, Genetics and Molecular Biology | 5 | 18% |
| Chemistry | 3 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 7% |
| Medicine and Dentistry | 2 | 7% |
| Other | 3 | 11% |
| Unknown | 7 | 25% |