Title |
Optogenetic Control of Transcription in Zebrafish
|
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Published in |
PLOS ONE, November 2012
|
DOI | 10.1371/journal.pone.0050738 |
Pubmed ID | |
Authors |
Hongtao Liu, Gustavo Gomez, Sophia Lin, Shuo Lin, Chentao Lin |
Abstract |
Light inducible protein-protein interactions are powerful tools to manipulate biological processes. Genetically encoded light-gated proteins for controlling precise cellular behavior are a new and promising technology, called optogenetics. Here we exploited the blue light-induced transcription system in yeast and zebrafish, based on the blue light dependent interaction between two plant proteins, blue light photoreceptor Cryptochrome 2 (CRY2) and the bHLH transcription factor CIB1 (CRY-interacting bHLH 1). We demonstrate the utility of this system by inducing rapid transcription suppression and activation in zebrafish. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 193 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 1% |
Canada | 2 | 1% |
Germany | 1 | <1% |
Australia | 1 | <1% |
India | 1 | <1% |
Japan | 1 | <1% |
Spain | 1 | <1% |
Unknown | 184 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 57 | 30% |
Researcher | 31 | 16% |
Student > Master | 21 | 11% |
Student > Bachelor | 18 | 9% |
Professor > Associate Professor | 14 | 7% |
Other | 31 | 16% |
Unknown | 21 | 11% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 78 | 40% |
Biochemistry, Genetics and Molecular Biology | 38 | 20% |
Neuroscience | 14 | 7% |
Chemistry | 12 | 6% |
Medicine and Dentistry | 7 | 4% |
Other | 20 | 10% |
Unknown | 24 | 12% |