| Title |
TBK1 Kinase Addiction in Lung Cancer Cells Is Mediated via Autophagy of Tax1bp1/Ndp52 and Non-Canonical NF-κB Signalling
|
|---|---|
| Published in |
PLOS ONE, November 2012
|
| DOI | 10.1371/journal.pone.0050672 |
| Pubmed ID | |
| Authors |
Alice C. Newman, Caroline L. Scholefield, Alain J. Kemp, Michelle Newman, Edward G. McIver, Ahmad Kamal, Simon Wilkinson |
| Abstract |
K-Ras dependent non-small cell lung cancer (NSCLC) cells are 'addicted' to basal autophagy that reprograms cellular metabolism in a lysosomal-sensitive manner. Here we demonstrate that the xenophagy-associated kinase TBK1 drives basal autophagy, consistent with its known requirement in K-Ras-dependent NSCLC proliferation. Furthermore, basal autophagy in this context is characterised by sequestration of the xenophagy cargo receptor Ndp52 and its paralogue Tax1bp1, which we demonstrate here to be a bona fide cargo receptor. Autophagy of these cargo receptors promotes non-canonical NF-κB signalling. We propose that this TBK1-dependent mechanism for NF-κB signalling contributes to autophagy addiction in K-Ras driven NSCLC. |
Mendeley readers
The data shown below were compiled from readership statistics for 86 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 1% |
| Unknown | 85 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 22 | 26% |
| Researcher | 15 | 17% |
| Student > Master | 10 | 12% |
| Professor > Associate Professor | 6 | 7% |
| Student > Bachelor | 4 | 5% |
| Other | 14 | 16% |
| Unknown | 15 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 27 | 31% |
| Biochemistry, Genetics and Molecular Biology | 25 | 29% |
| Immunology and Microbiology | 6 | 7% |
| Neuroscience | 4 | 5% |
| Medicine and Dentistry | 3 | 3% |
| Other | 3 | 3% |
| Unknown | 18 | 21% |