Report for: Cerebrospinal Fluid Matrix Metalloproteinases Are Elevated in Cerebral Adrenoleukodystrophy and Correlate with MRI Severity and Neurologic Dysfunction

Title	Cerebrospinal Fluid Matrix Metalloproteinases Are Elevated in Cerebral Adrenoleukodystrophy and Correlate with MRI Severity and Neurologic Dysfunction
Published in	PLOS ONE, November 2012
DOI	10.1371/journal.pone.0050430
Pubmed ID	23185624
Authors	Kathryn A. Thibert, Gerald V. Raymond, David R. Nascene, Weston P. Miller, Jakub Tolar, Paul J. Orchard, Troy C. Lund
Abstract	X-linked adrenoleukodystrophy results from mutations in the ABCD1 gene disrupting the metabolism of very-long-chain fatty acids. The most serious form of ALD, cerebral adrenoleukodystrophy (cALD), causes neuroinflammation and demyelination. Neuroimaging in cALD shows inflammatory changes and indicates blood-brain-barrier (BBB) disruption. We hypothesize that disruption may occur through the degradation of the extracellular matrix defining the BBB by matrix metalloproteinases (MMPs). MMPs have not been evaluated in the setting of cALD.

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United Kingdom	1	100%

Type	Count	As %
Science communicators (journalists, bloggers, editors)	1	100%

Mendeley readers

The data shown below were compiled from readership statistics for 44 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Readers by professional status	Count	As %
Student > Ph. D. Student	7	16%
Other	6	14%
Student > Master	6	14%
Researcher	5	11%
Student > Bachelor	3	7%
Other	7	16%
Unknown	10	23%

Readers by discipline	Count	As %
Medicine and Dentistry	11	25%
Neuroscience	7	16%
Nursing and Health Professions	2	5%
Agricultural and Biological Sciences	2	5%
Computer Science	2	5%
Other	8	18%
Unknown	12	27%

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