Title |
Drug-Eluting Fibers for HIV-1 Inhibition and Contraception
|
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Published in |
PLOS ONE, November 2012
|
DOI | 10.1371/journal.pone.0049792 |
Pubmed ID | |
Authors |
Cameron Ball, Emily Krogstad, Thanyanan Chaowanachan, Kim A. Woodrow |
Abstract |
Multipurpose prevention technologies (MPTs) that simultaneously prevent sexually transmitted infections (STIs) and unintended pregnancy are a global health priority. Combining chemical and physical barriers offers the greatest potential to design effective MPTs, but integrating both functional modalities into a single device has been challenging. Here we show that drug-eluting fiber meshes designed for topical drug delivery can function as a combination chemical and physical barrier MPT. Using FDA-approved polymers, we fabricated nanofiber meshes with tunable fiber size and controlled degradation kinetics that facilitate simultaneous release of multiple agents against HIV-1, HSV-2, and sperm. We observed that drug-loaded meshes inhibited HIV-1 infection in vitro and physically obstructed sperm penetration. Furthermore, we report on a previously unknown activity of glycerol monolaurate (GML) to potently inhibit sperm motility and viability. The application of drug-eluting nanofibers for HIV-1 prevention and sperm inhibition may serve as an innovative platform technology for drug delivery to the lower female reproductive tract. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 6 | 32% |
United Kingdom | 2 | 11% |
Nigeria | 1 | 5% |
Unknown | 10 | 53% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 12 | 63% |
Scientists | 4 | 21% |
Practitioners (doctors, other healthcare professionals) | 3 | 16% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
France | 2 | 2% |
Portugal | 1 | <1% |
Ireland | 1 | <1% |
Canada | 1 | <1% |
Unknown | 119 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 32 | 26% |
Student > Master | 17 | 14% |
Researcher | 10 | 8% |
Student > Bachelor | 10 | 8% |
Student > Postgraduate | 8 | 6% |
Other | 14 | 11% |
Unknown | 33 | 27% |
Readers by discipline | Count | As % |
---|---|---|
Materials Science | 13 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 13 | 10% |
Medicine and Dentistry | 12 | 10% |
Engineering | 11 | 9% |
Chemistry | 10 | 8% |
Other | 30 | 24% |
Unknown | 35 | 28% |