| Title |
Study of Association of CD40-CD154 Gene Polymorphisms with Disease Susceptibility and Cardiovascular Risk in Spanish Rheumatoid Arthritis Patients
|
|---|---|
| Published in |
PLOS ONE, November 2012
|
| DOI | 10.1371/journal.pone.0049214 |
| Pubmed ID | |
| Authors |
Mercedes García-Bermúdez, Carlos González-Juanatey, Raquel López-Mejías, María Teruel, Alfonso Corrales, José A. Miranda-Filloy, Santos Castañeda, Alejandro Balsa, Benjamín Fernández-Gutierrez, Isidoro González-Álvaro, Carmen Gómez-Vaquero, Ricardo Blanco, Javier Llorca, Javier Martín, Miguel A. González-Gay |
| Abstract |
Rheumatoid arthritis (RA) is a chronic inflammatory disease associated with increased cardiovascular (CV) mortality. Since CD40-CD154 binding has direct consequences on inflammation process initiation, we aimed to replicate previous findings related to disease susceptibility in Spanish RA population. Furthermore, as the major complication in RA disease patients is the development of CV events due to accelerated atherosclerosis, and elevated levels of CD40L/CD154 are present in patients with acute myocardial infarction, we assessed the potential association of CD40 and CD154/CD40L gene variants with CV risk in Spanish RA patients. |
Mendeley readers
The data shown below were compiled from readership statistics for 57 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Colombia | 1 | 2% |
| Unknown | 56 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 14 | 25% |
| Student > Doctoral Student | 8 | 14% |
| Other | 6 | 11% |
| Student > Master | 5 | 9% |
| Student > Ph. D. Student | 4 | 7% |
| Other | 11 | 19% |
| Unknown | 9 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 20 | 35% |
| Biochemistry, Genetics and Molecular Biology | 7 | 12% |
| Immunology and Microbiology | 6 | 11% |
| Agricultural and Biological Sciences | 2 | 4% |
| Psychology | 2 | 4% |
| Other | 4 | 7% |
| Unknown | 16 | 28% |