Title |
A20 Controls Macrophage to Elicit Potent Cytotoxic CD4+ T Cell Response
|
---|---|
Published in |
PLOS ONE, November 2012
|
DOI | 10.1371/journal.pone.0048930 |
Pubmed ID | |
Authors |
Lifeng Wang, Bangxing Hong, Xiaoxia Jiang, Lindsey Jones, Si-Yi Chen, Xue F. Huang |
Abstract |
Emerging evidence indicates that CD4(+) T cells possess cytotoxic potential for tumor eradication and perforin/granzyme-mediated cytotoxicity functions as one of the important mechanisms for CD4(+) T cell-triggered cell killing. However, the critical issue is how the cytotoxic CD4(+) T cells are developed. During the course of our work that aims at promoting immunostimulation of APCs by inhibition of negative regulators, we found that A20-silenced Mф drastically induced granzyme B expression in CD4(+) T cells. As a consequence, the granzyme-highly expressing CD4(+) T cells exhibited a strong cytotoxic activity that restricted tumor development. We found that A20-silenced Mф activated cytotoxic CD4(+) T cells by MHC class-II restricted mechanism and the activation was largely dependent on enhanced production of IFN-γ. |
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Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
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Unknown | 20 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 7 | 35% |
Student > Master | 4 | 20% |
Student > Ph. D. Student | 3 | 15% |
Student > Doctoral Student | 1 | 5% |
Professor | 1 | 5% |
Other | 1 | 5% |
Unknown | 3 | 15% |
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Computer Science | 1 | 5% |
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Unknown | 3 | 15% |