| Title |
Hyperglycemia-Induced Abnormalities in Rat and Human Corneas: The Potential of Second Harmonic Generation Microscopy
|
|---|---|
| Published in |
PLOS ONE, November 2012
|
| DOI | 10.1371/journal.pone.0048388 |
| Pubmed ID | |
| Authors |
Gaël Latour, Laura Kowalczuk, Michèle Savoldelli, Jean-Louis Bourges, Karsten Plamann, Francine Behar-Cohen, Marie-Claire Schanne-Klein |
| Abstract |
Second Harmonic Generation (SHG) microscopy recently appeared as an efficient optical imaging technique to probe unstained collagen-rich tissues like cornea. Moreover, corneal remodeling occurs in many diseases and precise characterization requires overcoming the limitations of conventional techniques. In this work, we focus on diabetes, which affects hundreds of million people worldwide and most often leads to diabetic retinopathy, with no early diagnostic tool. This study then aims to establish the potential of SHG microscopy for in situ detection and characterization of hyperglycemia-induced abnormalities in the Descemet's membrane, in the posterior cornea. |
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 35 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 3% |
| India | 1 | 3% |
| Switzerland | 1 | 3% |
| Unknown | 32 | 91% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 6 | 17% |
| Researcher | 6 | 17% |
| Student > Bachelor | 5 | 14% |
| Student > Postgraduate | 4 | 11% |
| Student > Master | 3 | 9% |
| Other | 6 | 17% |
| Unknown | 5 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Physics and Astronomy | 14 | 40% |
| Medicine and Dentistry | 5 | 14% |
| Agricultural and Biological Sciences | 4 | 11% |
| Engineering | 3 | 9% |
| Chemistry | 2 | 6% |
| Other | 1 | 3% |
| Unknown | 6 | 17% |