Title |
CNS SIRT3 Expression Is Altered by Reactive Oxygen Species and in Alzheimer’s Disease
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Published in |
PLOS ONE, November 2012
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DOI | 10.1371/journal.pone.0048225 |
Pubmed ID | |
Authors |
Heather J. M. Weir, Tracey K. Murray, Patrick G. Kehoe, Seth Love, Eric M. Verdin, Michael J. O’Neill, Jon D. Lane, Nina Balthasar |
Abstract |
Progressive mitochondrial dysfunction contributes to neuronal degeneration in age-mediated disease. An essential regulator of mitochondrial function is the deacetylase, sirtuin 3 (SIRT3). Here we investigate a role for CNS Sirt3 in mitochondrial responses to reactive oxygen species (ROS)- and Alzheimer's disease (AD)-mediated stress. Pharmacological augmentation of mitochondrial ROS increases Sirt3 expression in primary hippocampal culture with SIRT3 over-expression being neuroprotective. Furthermore, Sirt3 expression mirrors spatiotemporal deposition of β-amyloid in an AD mouse model and is also upregulated in AD patient temporal neocortex. Thus, our data suggest a role for SIRT3 in mechanisms sensing and tackling ROS- and AD-mediated mitochondrial stress. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 4% |
Finland | 1 | 1% |
Germany | 1 | 1% |
Unknown | 71 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 19 | 25% |
Researcher | 14 | 18% |
Student > Master | 10 | 13% |
Professor > Associate Professor | 6 | 8% |
Student > Doctoral Student | 5 | 7% |
Other | 9 | 12% |
Unknown | 13 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 27 | 36% |
Medicine and Dentistry | 11 | 14% |
Neuroscience | 9 | 12% |
Biochemistry, Genetics and Molecular Biology | 5 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 5% |
Other | 5 | 7% |
Unknown | 15 | 20% |