| Title |
High-Fat Diet Induces Periodontitis in Mice through Lipopolysaccharides (LPS) Receptor Signaling: Protective Action of Estrogens
|
|---|---|
| Published in |
PLOS ONE, November 2012
|
| DOI | 10.1371/journal.pone.0048220 |
| Pubmed ID | |
| Authors |
Vincent Blasco-Baque, Matteo Serino, Jean-Noël Vergnes, Elodie Riant, Pascale Loubieres, Jean-François Arnal, Pierre Gourdy, Michel Sixou, Rémy Burcelin, Philippe Kemoun |
| Abstract |
A fat-enriched diet favors the development of gram negative bacteria in the intestine which is linked to the occurrence of type 2 diabetes (T2D). Interestingly, some pathogenic gram negative bacteria are commonly associated with the development of periodontitis which, like T2D, is characterized by a chronic low-grade inflammation. Moreover, estrogens have been shown to regulate glucose homeostasis via an LPS receptor dependent immune-modulation. In this study, we evaluated whether diet-induced metabolic disease would favor the development of periodontitis in mice. In addition, the regulatory role of estrogens in this process was assessed. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 126 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | <1% |
| Unknown | 125 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 22 | 17% |
| Student > Master | 17 | 13% |
| Student > Bachelor | 16 | 13% |
| Researcher | 15 | 12% |
| Student > Doctoral Student | 8 | 6% |
| Other | 25 | 20% |
| Unknown | 23 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 46 | 37% |
| Agricultural and Biological Sciences | 20 | 16% |
| Biochemistry, Genetics and Molecular Biology | 12 | 10% |
| Immunology and Microbiology | 9 | 7% |
| Nursing and Health Professions | 4 | 3% |
| Other | 9 | 7% |
| Unknown | 26 | 21% |