Title |
Tin Oxide Nanowires Suppress Herpes Simplex Virus-1 Entry and Cell-to-Cell Membrane Fusion
|
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Published in |
PLOS ONE, October 2012
|
DOI | 10.1371/journal.pone.0048147 |
Pubmed ID | |
Authors |
James Trigilio, Thessicar E. Antoine, Ingo Paulowicz, Yogendra K. Mishra, Rainer Adelung, Deepak Shukla |
Abstract |
The advent of nanotechnology has ushered in the use of modified nanoparticles as potential antiviral agents against diseases such as herpes simplex virus 1 and 2 (HSV-1) (HSV-2), human immunodeficiency virus (HIV), monkeypox virus, and hepatitis B virus. Here we describe the application of tin oxide (SnO(2)) nanowires as an effective treatment against HSV-1 infection. SnO(2) nanowires work as a carrier of negatively charged structures that compete with HSV-1 attachment to cell bound heparan sulfate (HS), therefore inhibiting entry and subsequent cell-to-cell spread. This promising new approach can be developed into a novel form of broad-spectrum antiviral therapy especially since HS has been shown to serve as a cellular co-receptor for a number of other viruses as well, including the respiratory syncytial virus, adeno-associated virus type 2, and human papilloma virus. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 2% |
Portugal | 1 | 2% |
Italy | 1 | 2% |
Unknown | 60 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 15 | 24% |
Student > Master | 7 | 11% |
Student > Ph. D. Student | 6 | 10% |
Student > Bachelor | 4 | 6% |
Student > Doctoral Student | 3 | 5% |
Other | 8 | 13% |
Unknown | 20 | 32% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 9 | 14% |
Materials Science | 7 | 11% |
Medicine and Dentistry | 4 | 6% |
Biochemistry, Genetics and Molecular Biology | 3 | 5% |
Immunology and Microbiology | 2 | 3% |
Other | 7 | 11% |
Unknown | 31 | 49% |