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Dissociation between Brain Amyloid Deposition and Metabolism in Early Mild Cognitive Impairment

Overview of attention for article published in PLOS ONE, October 2012
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Title
Dissociation between Brain Amyloid Deposition and Metabolism in Early Mild Cognitive Impairment
Published in
PLOS ONE, October 2012
DOI 10.1371/journal.pone.0047905
Pubmed ID
Authors

Liyong Wu, Jared Rowley, Sara Mohades, Antoine Leuzy, Marina Tedeschi Dauar, Monica Shin, Vladimir Fonov, Jianping Jia, Serge Gauthier, Pedro Rosa-Neto, the Alzheimer’s Disease Neuroimaging Initiative

Abstract

The hypothetical model of dynamic biomarkers for Alzheimer's disease (AD) describes high amyloid deposition and hypometabolism at the mild cognitive impairment (MCI) stage. However, it remains unknown whether brain amyloidosis and hypometabolism follow the same trajectories in MCI individuals. We used the concept of early MCI (EMCI) and late MCI (LMCI) as defined by the Alzheimer's disease Neuroimaging Initiative (ADNI)-Go in order to compare the biomarker profile between EMCI and LMCI.

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Mendeley readers

The data shown below were compiled from readership statistics for 80 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 1%
United States 1 1%
Unknown 78 98%

Demographic breakdown

Readers by professional status Count As %
Student > Master 12 15%
Researcher 10 13%
Student > Ph. D. Student 9 11%
Professor 7 9%
Student > Bachelor 6 8%
Other 19 24%
Unknown 17 21%
Readers by discipline Count As %
Neuroscience 12 15%
Medicine and Dentistry 11 14%
Psychology 10 13%
Agricultural and Biological Sciences 4 5%
Biochemistry, Genetics and Molecular Biology 3 4%
Other 12 15%
Unknown 28 35%