Title |
Central Projection of Pain Arising from Delayed Onset Muscle Soreness (DOMS) in Human Subjects
|
---|---|
Published in |
PLOS ONE, October 2012
|
DOI | 10.1371/journal.pone.0047230 |
Pubmed ID | |
Authors |
Katharina Zimmermann, Caroline Leidl, Miriam Kaschka, Richard W. Carr, Pavel Terekhin, Hermann O. Handwerker, Clemens Forster |
Abstract |
Delayed onset muscle soreness (DOMS) is a subacute pain state arising 24-48 hours after a bout of unaccustomed eccentric muscle contractions. Functional magnetic resonance imaging (fMRI) was used to examine the patterns of cortical activation arising during DOMS-related pain in the quadriceps muscle of healthy volunteers evoked by either voluntary contraction or physical stimulation. The painful movement or physical stimulation of the DOMS-affected thigh disclosed widespread activation in the primary somatosensory and motor (S1, M1) cortices, stretching far beyond the corresponding areas somatotopically related to contraction or physical stimulation of the thigh; activation also included a large area within the cingulate cortex encompassing posteroanterior regions and the cingulate motor area. Pain-related activations were also found in premotor (M2) areas, bilateral in the insular cortex and the thalamic nuclei. In contrast, movement of a DOMS-affected limb led also to activation in the ipsilateral anterior cerebellum, while DOMS-related pain evoked by physical stimulation devoid of limb movement did not. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Netherlands | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 50% |
Scientists | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 1 | 1% |
Denmark | 1 | 1% |
Brazil | 1 | 1% |
Unknown | 78 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 15 | 19% |
Student > Ph. D. Student | 13 | 16% |
Student > Bachelor | 9 | 11% |
Researcher | 9 | 11% |
Student > Postgraduate | 9 | 11% |
Other | 13 | 16% |
Unknown | 13 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 22 | 27% |
Sports and Recreations | 9 | 11% |
Neuroscience | 8 | 10% |
Psychology | 6 | 7% |
Nursing and Health Professions | 5 | 6% |
Other | 12 | 15% |
Unknown | 19 | 23% |