| Title |
The Prognostic Value of BRAF Mutation in Colorectal Cancer and Melanoma: A Systematic Review and Meta-Analysis
|
|---|---|
| Published in |
PLOS ONE, October 2012
|
| DOI | 10.1371/journal.pone.0047054 |
| Pubmed ID | |
| Authors |
Gholamreza Safaee Ardekani, Seyed Mehdi Jafarnejad, Larry Tan, Ardavan Saeedi, Gang Li |
| Abstract |
Mutation of BRAF is a predominant event in cancers with poor prognosis such as melanoma and colorectal cancer. BRAF mutation leads to a constitutive activation of mitogen activated protein kinase pathway which is essential for cell proliferation and tumor progression. Despite tremendous efforts made to target BRAF for cancer treatment, the correlation between BRAF mutation and patient survival is still a matter of controversy. |
Mendeley readers
The data shown below were compiled from readership statistics for 145 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Finland | 1 | <1% |
| Ireland | 1 | <1% |
| Brazil | 1 | <1% |
| Unknown | 142 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 22 | 15% |
| Researcher | 22 | 15% |
| Other | 18 | 12% |
| Student > Master | 14 | 10% |
| Student > Doctoral Student | 13 | 9% |
| Other | 29 | 20% |
| Unknown | 27 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 58 | 40% |
| Agricultural and Biological Sciences | 17 | 12% |
| Biochemistry, Genetics and Molecular Biology | 15 | 10% |
| Neuroscience | 3 | 2% |
| Engineering | 3 | 2% |
| Other | 12 | 8% |
| Unknown | 37 | 26% |